Offering a highest location 4.5 km from the sand Red Beach, the 5-star Vedema, A Luxury Collection Resort, Santorini Megalochori has an archaeological museum. Located right near the village of Megalochori, the hotel features a private swimming pool for guests to relax in.

This Megalochori resort is superbly situated 10 minutes by car from the Kamari Beach. The atmospheric Art Space Gallery is in close proximity to the Vedema, A Luxury Collection Resort, Santorini Megalochori, while Venetsanos bus stop is 450 metres away. Hot springs are near the accommodation. This smoke-free hotel is located a mere 5 minutes' walk from Megalochori Clock Tower, in Megalochori. For those travelling from afar, Santorini International airport is 9 minutes' drive away.

The rooms at Vedema, A Luxury Collection Resort, Santorini include an air conditioner. Some of them comprise a dressing area and a dining area, furnished with a writing table. This property has 73 spacious rooms with views of the sea.

The hotel offers a vegetarian breakfast daily. The Greek Alati restaurant serves seafood food. To cater to every palate, it offers a vegetarian menu. Guests are invited to the onsite lounge bar to unwind with a drink. The bar area includes a lounge. There is a restaurant serving Greek food around 100 metres away.