Located 4.7 km from the sand Red Beach, the 5-star Vedema, A Luxury Collection Resort, Santorini Megalochori boasts an archaeological museum. The hotel has a banquet hall, inspired by moments of togetherness, and is situated just around the corner from the village of Megalochori.

This Megalochori resort lies only 350 m from the Symposion by La Ponta and offers views of the Aegean Sea. The Ancient Thera is in close proximity to the Vedema Megalochori, while Venetsanos bus stop is about 5 minutes' walk away. The accommodation is located near hot springs in the neighbourhood. Guests can find the Castelli of Pyrgos, which is 2.4 km away. For those travelling from afar, Santorini International airport is 9 minutes' drive away.

Looking onto the patio, some rooms at Vedema, A Luxury Collection Resort, Santorini offer a fireplace and sound-proof windows furnished with a writing table. Along with a mini fridge bar and coffee/tea making machines, they also have free wireless internet and a flat-screen TV with satellite channels to keep you entertained. The additional bathrooms are appointed with an additional toilet and a sauna, and such comforts as shower caps and bath sheets.

A vegetarian breakfast is offered at the Vedema. This smoke-free hotel has a Greek Pergola restaurant that serves Greek dishes. Guests are invited to the onsite pool bar to unwind with a drink. The bar area includes a lounge. There is a restaurant serving Greek food around 100 metres away.