Located nearly a 5-minute walk from University of the Aegean, the 3-star Thalia'S Garden Hotel Mytilene gives quick access to various city sites.

Saint Therapon is 800 m from the guest house, and the Temple of Aphrodite is not far from it. The early 19th century mosque "Museum of Byzantine Art" is also merely 10 minutes' walk away. The Thalia'S Garden Mytilene is situated a mere 1.3 km from the Pessa Springs, while Lesvos Intercity bus station lies a mere 0.9 km away. For those travelling from afar, Mytilene International "Odysseas Elytis" airport is 10 minutes' drive away.

The rooms include soundproof windows, along with wardrobes for guests' comfort. A flat-screen TV with satellite channels, as well as comforts as an air conditioner are also featured. Offering a separate toilet and a shower, the bathrooms are fitted with hairdryers and bath sheets.

The restaurant Gamatastra is located steps away from Thalia'S Garden Hotel.