Located nearly 5 minutes' walk from Aegean Sea, the contemporary Proteas Blu Resort Pythagoreio includes 103 air-conditioned rooms. With a location 2.7 km from the Castle of Lykourgos Logothetis, the 5-star smoke-free hotel also features a ballroom for multiple types of social activities.

The resort is situated in the coastal part of Pythagoreio, within 10 minutes' drive of the Pythagorion Archaeological Museum. Guests can find the 4000 long Aquaduct Tunnel of Eupalinos 2.6 km from the Proteas Blu Resort Pythagoreio. The private beach is located about a 15-minute walk away. The nearby notable religious buildings include the clifftop Monastery of Panagia Spiliani, within a 2-km distance of the property. For those travelling from afar, Samos airport is 10 minutes' drive away.

The air-conditioned rooms offer a flat screen TV and pay-per-view channels, and overlook the sea. They are furnished with a contemporary decor.

Proteas Blu Resort serves a free breakfast to all guests. Dining options include a Greek restaurant, which features international dishes as well as Greek restaurant with its European cuisine, and more. The beach bar is ideal for a relaxing drink. International cuisine is offered at Glicorisa Beach Bar Restaurant, situated in proximity to the Proteas Blu Resort.