Offering air-conditioned rooms and Wi-Fi in public areas, Nefeli Hotel Karlovassi is 200 metres from the Church of the Assumption of the Virgin Mary and 11 minutes' walk from the Folklore Museum. Located a stone's throw from the Agios Nikolaos Church, the hotel offers a poolside bar, a sundeck and a shared lounge.

This 2-star hotel is about 35 km from Samos airport and just 350 m from such cultural venues as the Karlovasi Tannery Museum. The Nefeli is also situated in close proximity to the Potami Beach. The property is 10 minutes by car from the Potami Waterfalls.

This Karlovassi hotel offers rooms with a patio and a balcony featuring an iron and climate control, along with wireless internet. They are furnished with sound-proofed windows, and also come with coffee and tea making facilities. Bathrooms include a separate toilet, a shower, and a sink, and such comforts as hairdryers and toiletries.

The restaurant Iris Cafe is situated fairly close to the smoke-free Nefeli Hotel.