Offering access to Agia Triada Monastery, which is approximately a 25-minute walk away, the 2-star family-run Mykali Hotel Pythagoreio features a shared lounge and a TV lounge. Situated on hills, this Pythagoreio hotel is within 2 km of the Pythagorion Archaeological Museum.

The hotel is located in Pythagoreio, a mere 30 metres from Aegean Sea. A sandy beach is about a 10-minute stroll away. You can easily find the clifftop Monastery of Panagia Spiliani 3.5 km from the Mykali Pythagoreio. For those travelling from afar, Samos airport is 10 minutes' drive away.

There are 58 rooms comprising an adjoining terrace and a balcony. They come with a flat-screen TV with satellite channels, as well as such comforts as climate control. A separate toilet and a shower, along with such amenities as hair dryers and towels, are also at guests' disposal.

Mykali Hotel offers a daily buffet breakfast. Offering Greek dishes, the Greek restaurant features sea views. Within reach of the accommodation, Glicorisa Beach Bar Restaurant serves Greek meals.