Karnayo Hotel Megisti is located a 16-minute walk from Cathedral of St. Constantine and St. Helen and boasts an archaeological museum. Guests who stay at this guest house can park their car nearby.

The 3-star hotel is about 5 km from Kastelorizo Island Public airport and in the vicinity of such cultural venues as the Popular Art Museum. The Blue Grotto is within a 700-metre distance of the Karnayo, and the Saint George Beach is 1.4 km away. You can also visit Megisti Port, located 5 minutes' walk away.

This property offers rooms with a kitchenette featuring air conditioning, along with a flat-screen TV with satellite channels. Bathrooms include a separate toilet and a shower, and such comforts as hairdryers and toiletries.

Guests can dine at the seafood restaurant Lazarakis, which is 250 metres away.