Nestled in a historic area, the 3-star Palazzo Santa Maria Hotel Ermoupoli is nearly a 5-minute ride from culture-oriented attractions like Museum Mark Vamvakaris. This Ano Syros guest house also provides guests with a safe deposit box and fire extinguishers.

The property is 14 minutes on foot from Casino Syros and 10 minutes by car from Paralia Kini. The nearby places of worship include St. George's Cathedral (900 metres) and Saint Nicholas Church (0.8 km). Industrial museum of Ermoupolis is 20 minutes' stroll from the hotel. For those travelling from afar, Syros Island airport is 12 minutes' drive away.

The rooms at the Palazzo Santa Maria Ano Syros have a flat-screen TV with satellite channels, along with coffee/tea making equipment for your convenience. Furnished with a writing table, they also have soundproof windows. Bathrooms come with a tub, a walk-in shower, and a sink, along with shower caps and bath sheets.